East Carolina dominated Charlotte 48-22 in a commanding home performance, building a 21-0 first-quarter lead behind Katin Houser's offensive brilliance. Houser accounted for four total touchdowns, including two passing and two rushing scores, while TyMir Brown added a 45-yard pick-six to the Pirates' explosive attack. Despite Grayson Loftis connecting with Javen Nicholas for two long touchdown passes, the 49ers could never overcome their early deficit as East Carolina maintained control throughout.