Illinois dominated Duke 45-19 behind quarterback Luke Altmyer's three touchdown passes to three different receivers. The Blue Devils kept it close at halftime, trailing just 14-13 after Darian Mensah found Andrel Anthony for a late second-quarter score, but the Fighting Illini pulled away with a 31-6 second-half surge. Illinois showcased their ground attack with three rushing touchdowns, including late fourth-quarter scores from Collin Dixon and Ca'Lil Valentine that sealed the convincing road victory.