Pittsburgh dominated Central Michigan 45-17 behind quarterback Eli Holstein's stellar four-touchdown performance, including two scoring strikes to Raphael Williams Jr. The Panthers jumped out to an early lead and never looked back, building a commanding 24-3 advantage before the Chippewas briefly cut the deficit to seven in the third quarter. Pitt responded with 21 unanswered points to close out the game, punctuated by late rushing touchdowns from Juelz Goff and Ja'Kyrian Turner.