Pittsburgh exploded for a dominant 61-9 victory over Duquesne at Acrisure Stadium, highlighted by Eli Holstein's four touchdown passes and Desmond Reid's electric performance that included an 88-yard punt return TD and a 53-yard rushing score. The Panthers scored early and often, building a commanding 34-6 halftime lead as Cataurus Hicks hauled in two touchdown receptions. Pitt's offense proved unstoppable, capping their impressive showing with Bryce Yates' 60-yard touchdown catch in the final minutes.