Louisville steamrolled Eastern Kentucky 51-17 in a dominant season opener, racing to a commanding 41-0 lead by late in the second quarter. Isaac Brown's explosive performance featured touchdown runs of 31 and 68 yards, while Caullin Lacy electrified the home crowd with a 93-yard punt return touchdown. The Cardinals' offensive onslaught included seven touchdowns from six different players before the Colonels finally broke through with Vito Tisdale Jr.'s pick-six just before halftime.