Iowa State dominated South Dakota 55-7 in a season-opening rout at Jack Trice Stadium, scoring 41 unanswered points after the game was briefly tied at 7. Quarterback Rocco Becht threw for three touchdowns, including two to Benjamin Brahmer, while the Cyclones' ground attack contributed four rushing touchdowns from four different players. Kyle Konrardy added an impressive 63-yard field goal to close the first half as Iowa State's offense proved unstoppable throughout the contest.