Indiana dominated Michigan State 38-13 behind quarterback Fernando Mendoza's stellar four-touchdown performance, with two scoring strikes to Elijah Sarratt. After briefly trailing 10-7 in the second quarter, the Hoosiers seized control with 28 unanswered points, including a 29-yard touchdown run from Kaelon Black and a 48-yard bomb to Omar Cooper Jr. The Spartans struggled to find rhythm after Nick Marsh's second-quarter touchdown, managing just two field goals from Martin Connington in the lopsided defeat.